Products
| Order NO.: C620008-0005 | CAS : |
Recombinant Human Interleukin-8, 72a.a./CXCL8
| Synonym | ||
| Storage | -20°C | |
| Categories | Recombination Proteins |
| Cat NO. | Package | Price(USD) |
| C620008-0005 | 5 UG | 105.0 |
| Bulk orders? | ||
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Biological Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 10-100 ng/ml. Properties summary Interleukin-8 (IL-8) is encoded by the IL8 gene and produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles. There are many receptors capable to bind IL-8, the most affinity to IL-8 are receptors CXCR1, and CXCR2. As a member of the CXC chemokine family, function of IL-8 is the induction of chemotaxis in its target cells, like neutrophil granulocytes, basophils, and T-cells. IL-8 (72a.a.) has a 5-10-fold higher activity on neutrophil activation, compared to IL-8 (77 a.a.). IL-8 is often associated with inflammation and has been cited as a proinflammatory mediator in gingivitis and psoriasis.
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