Products
| Order NO.: C610003-0020 | CAS : |
Recombinant Human Interleukin-1 Receptor Antagonist
| Synonym | ||
| Storage | -20°C | |
| Categories | Recombination Proteins |
| Cat NO. | Package | Price(USD) |
| C610003-0020 | 20 UG | 105.0 |
| Bulk orders? | ||
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Source Escherichia coli. Properties summary Interleukin-1 receptor antagonist (IL-1RA) is a member of the IL-1 family. IL-1RA is secreted by various types of cells including immune cells, epithelial cells, and adipocytes, and is a natural inhibitor of the pro-inflammatory effect of IL-1β. This protein inhibits the activities of interleukin 1, alpha (IL-1α) and interleukin 1, beta (IL-1β), and modulates a variety of interleukin 1 related immune and inflammatory responses. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-RA. The regulated expression of IL-1RA in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1RA is markedly enhanced by IL-1, TNF-α, or PDGF. The protein shows 26 % amino acid homology to IL-1β and 19 % homology to IL-1α.
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